Environment, aging & future medicine : common challenges for society


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Summary:

Metabolism and Epigenetics
"Information carrying" metabolites seem to play a central role for regulating epigenetics, the reprogramming of genetic information by chemical modification of DNA and histones, finally leading to altered gene expression. This new concept has important and far-reaching consequences for human society, since the general public now foresees, for the first time, the impact of the environment, life style, health and social conditions on the human genome, an effect that appears to be fuelled by changes in metabolism and that might impact several generations. It may well represent a missing link in many otherwise unrelated pathologies, including the global threat of rapidly spreading metabolic diseases. In the frame of a multi-scale approach of the Idex CDP SYMER to tackle this complex problem, the workshop will present experimental strategies and tools in biology and mathematical modeling.

LIFE Meeting
The proportion of patients with at least two co-occurrent (or multimorbid) chronic diseases (MCD) – such as heart disease, diabetes, obstructive sleep apnea (OSA), liver diseases including Non-Alcoholic Fatty Liver Disease (NAFLD) and lower respiratory diseases including Chronic Obstructive Pulmonary Disease (COPD) – is increasing with age and is over 50% of patients aged 50. The healthcare burden is over 80% of global health costs. Multimorbid chronic diseases tend to cluster and evolve over time, defining temporal trajectories of diseases during which patients may consecutively experience multiple pathologies. Cancer often occurs as an integral part of such MCD trajectories, including in particular cancers of the lung or the liver, which share common etiological risk factors with many MCDs.
These trajectories can be curbed by actionable factors – such as weight, sleep quality and circadian re-alignment, reduction of dietary or recreational exposure to toxic agents, hypoxia and physical activity – towards health improvement. However, a number of factors largely escape individual control and are driven by wider societal and environmental contexts. These factors include access to care, urban design, exposure to pollution, and social inequalities.
The LIFE meeting will review the progresses made in our interdisciplinary program to tackle the challenges towards an innovative understanding of physical, biological, social, anthropological and environmental factors, focused on the patients’ health, and a healthy ageing.

Improvement of air quality

Urban air pollution is a major public health issue in both North and South countries. MobilAir, in a fundamentally interdisciplinary approach, aims to identify specific measures to significantly reduce urban air pollution and its impacts. Building on the disciplinary richness of the Grenoble campus, MobilAir is developing an integrated approach in the Grenoble urban area, a relevant pilot area. MobilAir aims to develop methods and tools that can be applied in other cities in France or abroad.

The presentations will focus on:
1) Research aimed at a new characterization of the population’s exposure to pollution through the oxidative potential of particulate matter.

2) An innovative and interdisciplinary population-based intervention between geographers, psychologists, transport and health economists, sociologists and epidemiologists aimed at understanding the levers for sustaining changes in mobility towards active mobility (walking or cycling). The challenge is to understand the role of contextual (location of activities, urban planning, etc.) and psychological (perception, intention, altruism, social norms, etc.) factors, beyond the dimensions of transport cost and time, in individual mobility choices.

3) Support for public decision-making through the development of an interdisciplinary tool for evaluating urban policies to reduce pollution on mobility, traffic, the environment, health and the economy. The research also includes the development of a reverse modeling tool that aims to identify public measures on traffic and heating to achieve a given health objective.

EIT Health Session
EIT Health is a network of best-in-class health innovators backed by the EU. We deliver solutions to enable European citizens to live longer, healthier lives by promoting innovation. We connect the right people and the right topics across European borders, so that innovation can happen at the intersection of research, education and business – for the benefit of citizens.

Detailed programme:

Monday 3 June
10:30am - 12:30pm Metabolism and Epigenetics
Chairman: Uwe Schlattner

10:30 - 11:00 by Saadi Khochbin, Senior Research Scientist, Head of "Signaling and Chromatin" department - IAB, Univ. Grenoble Alpes

11:00 - 11:30 by Hidde de Jong, Senior Research Scientist - Inria - Grenoble Rhône-Alpes

11:30 - 12:00 by Daniel Jost, CNRS Research Associate - TIMC-IMAG, Univ. Grenoble Alpes / LBMC, ENS Lyon

12:00 - 12:30 by Uwe Schlattner, Professor - Director of LBFA, Univ. Grenoble Alpes
12:30pm - 2pm Lunch
2pm - 4pm LIFE Meeting

2:00 - 2:30 LIFE’s Project Introduction – Patients are at the heart of LIFE
- Jean-Louis Pépin, Head of the Clinic of Physiology, Sleep and Exercise department, Scientific Director of Clinical Research Administration and presides the Research Division - Grenoble University Hospital

2:30 - 2:50 The data of patients’ trajectories
- Behrooz Omidvar-Tehrani, Post-doctoral researcher in Computer Science - Univ. Grenoble Alpes
- Mai Thai Son, Lecturer in Cyber-Physical Systems at the Department of Electronics and Computer Science (ECS) - University of Southampton
- Sihem Amer-Yahia, Director of research - LIG, Univ. Grenoble Alpes

2:50 - 3:10 The biology of patients
- Sophie Rousseaux, French Institute of Health and Medical Research - Inserm
- Saadi Khochbin, Senior Research Scientist, Head of «Signaling and Chromatin» department - IAB, Univ. Grenoble Alpes


3:10 - 3:30 The environment of patients: the exposome approach
- Alicia Guillien, Post-doctoral researcher in respiratory epidemiology - IAB, Univ. Grenoble Alpes
- Valérie Siroux, Respiratory epidemiologist - IAB, Univ. Grenoble Alpes, Inserm

3:30 - 4:00 LIFE’s Future challenges & Discussion
- Jean-Louis Pépin, Head of the Clinic of Physiology, Sleep and Exercise department, Scientific Director of Clinical Research Administration and presides the Research Division - Grenoble University Hospital
4pm - 4:30pm Coffee break
4:30pm - 6pm
EIT Health Session

4:30 - 4:45 EIT Health in Grenoble: a success story for innovation and research & SEB : a successful partnership
- Jean-Louis Pépin, Head of the Clinic of Physiology, Sleep and Exercise department, Scientific Director of Clinical Research Administration and presides the Research Division - Grenoble University Hospital
- Christophe Moinard - LBFA, Univ. Grenoble Alpes
- SEB representative


4:45 - 5:10 Co-creation with patients and health providers
- Joan Escarabill, MD, PhD Director Chronic Care Program - Hospital Clínic (Barcelona)

5:10 - 5:17 POLLAR
- Marie Joyeux-Faure - HP2 laboratory, Univ. Grenoble Alpes
- Ingrid Jullian-Desayes, Post-doctoral researcher - HP2 laboratory, Univ. Grenoble Alpes


5:17 - 5:24 Sensapnea
- Jean-Louis Pépin, Head of the Clinic of Physiology, Sleep and Exercise department, Scientific Director of Clinical Research Administration and presides the Research Division - Grenoble University Hospital

5:24 - 5:32 Cook2Health
- Christophe Moinard - LBFA, Univ. Grenoble Alpes

5:32 - 5:40 VIP Room - VIrtual reality for oPerating Room : the room of success
- Caroline Landelle - TIMC-IMAG, Univ. Grenoble Alpes

5:40 - 6:00 EIT Health and future medicine
- Jean Marc Bourez, Managing Director EIT Health France
Tuesday 4 June
10:30am - 12:30pm Improvement of air quality

Particulate air pollution
- Jean-Luc Jaffrezo, CNRS Senior researcher - IGE, Univ. Grenoble Alpes

Development of an intervention to change mobility behaviour
- Aïna Chalabaev, Associate Professor an Head of the SENS laboratory - Univ. Grenoble Alpes

Identification of public policies allowing to reach a public health target by acting on atmospheric pollution sources. 
- Rémy Slama, Inserm Senior investigator - IAB, Univ. Grenoble Alpes
12:30pm - 2pm Lunch
2pm - 4pm Panel Discussion - Future medicine: an environmental and societal challenge to share with the citizen and patients

2:00 - 2:15 Introduction – The university as a way to address this challenge

2:15 - 3:45 Endocrine disruptors
- Rémy Slama, Inserm Senior investigator - IAB, Univ. Grenoble Alpes
- Claire Phillipat, PhD student - MIND Institute (Medical Investigation of Neurodevelopmental Disorders)


How to improve healthcare access
- Héléna Revil, Sciences Po Grenoble - Pacte, laboratoire de sciences sociales, Univ. Grenoble Alpes
- Phillipe Warin, CNRS - Pacte, laboratoire de sciences sociales, Univ. Grenoble Alpes


Shared projects to improve the healthcare system
- Joan Escarabill, MD, PhD Director Chronic Care Program - Hospital Clínic (Barcelona)

Sleep, health and society
- Jean-Louis Pépin, Head of the Clinic of Physiology, Sleep and Exercise department, Scientific Director of Clinical Research Administration and presides the Research Division - Grenoble University Hospital,

Public policies and urbanism
- Stéphane Sadoux, Deputy Director - AE&CC, Univ. Grenoble Alpes

3:45 - 4:00 Conclusion
- Jean-Louis Pépin, Head of the Clinic of Physiology, Sleep and Exercise department, Scientific Director of Clinical Research Administration and presides the Research Division - Grenoble University Hospital,


Main speakers:

Jean-Marc BourezJean-Marc Bourez
Managing Director - EIT Health France
Aïna Chalabaev
Aïna Chalabaev

Associate Professor an Head of the SENS laboratory - Univ. Grenoble Alpes

Her work focuses on the motivational factors of physical activity behaviors in inactive populations (e.g., seniors, overweight people, women, people with chronic diseases). This research takes place in the context of the growing sedentarity of the population, which constitutes a major public health issue as it is a leading cause of incapacities and diseases. In this context, her research aims at identifying barriers and motivational levers to regular physical activity. This questioning is examined within the field of social psychology.
Hidde de JongHidde de Jong
Senior Research Scientist - Inria - Grenoble Rhône-Alpes

Hidde de Jong joined INRIA Grenoble - Rhône-Alpes in 1998, where he is currently a senior research scientist. He is head of the IBIS group, involving researchers from  INRIA and University Grenoble Alpes, focusing on the analysis of bacterial regulatory networks by means of experimental and modelling approaches. For more information, see http://team.inria.fr/ibis.
Joan EscarabillJoan Escarabill
MD, PhD Director Chronic Care Program - Hospital Clínic (Barcelona)

Respiratory physician and Director of the Chronic Care Program at Hospital Clínic (Barcelona), Joan Escarabill is involved in transversal policies regarding information and therapeutic education, transitional care, geriatric care and adherence programs and management of polypharmacy.
Jean-Luc Jaffrezo

Jean-Luc Jaffrezo

CNRS Senior researcher - IGE, Univ. Grenoble Alpes

His research focuses on tropospheric chemistry of gases and aerosols, with applications to air quality and analytical chemistry for the atmospheric environment.
Daniel JostDaniel Jost
CNRS Research Associate - TIMC-IMAG, Univ. Grenoble Alpes / LBMC, ENS Lyon

Daniel Jost is a CNRS Research Associate, expert in computational and physical modeling of living systems. His current researches focus on the spatio-temporal dynamics of chromatin. In particular, he made key contributions in the understanding of the 3D epigenome organization inside cell nuclei. After 4 years at TIMC-IMAG (CNRS, University Grenoble-Alpes) in the Mathematical and Computational Biology Team, he recently joined the Laboratory of Biology and Modeling of the Cell (CNRS, ENS Lyon) as a young group leader to develop his modeling activities on chromatin regulation and organization. More details can be found at http://perso.ens-lyon.fr/daniel.jost/
Saadi KhochbinSaadi Khochbin
Senior Research Scientist, Head of "Signaling and Chromatin" department - IAB, Univ. Grenoble Alpes

After university studies in Iran and France (Paris and Grenoble), Saadi Khochbin obtained his PhD in Biology in 1990 in Grenoble. Following a postdoctoral fellowship at the National Institute of Health (USA), he joined the Inserm Unit U309 and created his team, first at CEN-G in 1992 and then at the Institute for Advanced Biosciences (IAB) in 1995. Since 2002, Dr. Saadi KHOCHBIN is Head of the IAB Signaling and Chromatin Department and leads his own team "Epigenetics and Cell Signaling". His team’s research aims at the understanding of how the genome communicates with its close or distant environment to control its various activities. In October 2014, he received the CNRS silver medal.
Uwe SchlattnerUwe Schlattner
Professor - Director of LBFA, Univ. Grenoble Alpes

Uwe Schlattner joined the Université Grenoble Alpes in 2006 as professor and team leader of the Laboratory of Fundamental and Applied Bioenergetics (LBFA). Since 2011, he is Head of the LBFA. His team does research in Cell Biology, Molecular Biology and Physiology, in particular on the molecular physiology of kinases in energy homeostasis. His current projects involve AMP-activated protein kinase and mitochondrial members of the NME/NDPK family. In parallel, since 2010, Uwe is Director of the federative structure « Environnemental and Systems Biology » (BEeSy), Université Grenoble Alpes. This SFR intends to merge different classical disciplines to develop and apply integrative and systemic approaches.

Rémy Slama Rémy Slama
Inserm Senior investigator - IAB, Univ. Grenoble Alpes 

Rémy Slama is senior investigator at Inserm in environmental epidemiology, affiliated to IAB (Institute for Advanced Biosciences, Grenoble), where he leads the Team of Environmental Epidemiology. His research topics include the impact of environmental factors (air pollutants, endocrine disruptors, the Exposome) on human reproduction, development, and child health.